Final Program

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June 30

18.30-18.45

Opening Ceremony

18.45-19.30

OL
Aldo Roda
University of Bologna, Bologna, Italy
Toward Three RS Rules: Reduction, Replacement and Refinement Alternative to Animal Experiments For Drug Discovery Using Bioluminescence Cell-Based and in Vivo Imaging Approaches

20.00

Welcome buffet

 

July 1

9.00-9.45

PL1
Jean-Luc Veuthey
University of Geneva, Geneva, Switzerland
New Strategies for the Analysis of Pharmaceutical Compounds

9.45.-9:50

Technical break

 

ADVANCED ANALYTICAL TECHNIQUES FOR PROTEOMICS, GLYCOMICS, METABOLOMICS AND LIPIDOMICS I
Biomarker analysis and metabolic profiling

DRUG ANALYSIS I
Counterfeit drugs and natural compounds

9:50-10.20 KN1. Mass spectrometry-based quantitation of biomolecules: proteomics, metabolomics and beyond
Igor Kaltashov, University of Massachusetts, Amherst, MA, USA
KN2. Analytical strategies for the detection and characterization of counterfeit medicines
Jaques Crommen, University de Li?ge, Li?ge, Belgium
10.20-10.40 OC1. Targeted biomarker analysis by combined immunoaffinity and LC-MS/MS potential and possibilities
Trine G. Halvorsen, University of Oslo, Oslo, Norway
OC6. Chromatographic fingerprints to discriminate counterfeit medicines and characterize illegal pharmaceutical preparations.
Eric Deconinck, Scientific Institute of Public Health (WIV-ISP), Brussels, Belgium
10.40-11.00 OC2. Digging deep in the field of SCLC-biomarkers ProGRP and NSE. Synergy of immunocapture and LC-SRM-MS for clinical use
Silje Torsetnes, University of Oslo, Oslo, Norway
OC7. NMR, a powerful technique for the screening of adulterants in dietary supplements
Myriam Malet-Martino, University Paul Sabatier, Toulouse, France

11:00:11:30

Coffee break

11:30-11.50 OC3. Anionic metabolic profiling of urine by CE-MS and HILIC-MS
Miranda Kok, Utrecht University, Utrecht, The Netherlands
OC8. Market survey of illegal lightening cosmetics on the Belgium market
Bart Desmedt, Scientific Institute of Public Health - Vrije Universiteit Brussel (VUB), Brussels, Belgium
11:50-12:10 OC4. Ultra low-flow sheathless capillary electrophoresis-mass spectrometry for in-depth profiling of ionogenic metabolites in body fluids
Rawi Ramautar, Leiden University, Leiden, The Netherlands
OC9. Analytical design space strategy for the development of LC methods to combat potentially counterfeit antibiotic drugs
Amandine Dispas, University of Li?ge, Li?ge, Belgium
12:10-12:30 OC5. Applications of quantitative structure-retention relationships (QSRR) in "omics"
Roman Kalizan, Medical University of Gdansk, Gdansk, Poland
OC10. Analysis of amino acids and related compounds in fruits by CE-LIF and LC-FL
Roberto Mandrioli, University of Bologna, Bologna, Italy
12.30-13.00 KN3. Mass spectrometry of covalent protein binding: applications in drug discovery
Giancarlo Aldini, University of Milan, Milan, Italy
KN4. Miniaturized technological approaches for identifying new drug-leads and biomarkers from natural sources
Jean-Luc Wolfender, University of Geneva, Geneva, Switzerland

13.00-14-00

Lunch

13:10-14:10: Luncheon seminar
UltraPerformance Convergence Chromatography: Expanding Selectivity for the Chromatographic Laboratory
H?l?ne Boiteux
Business Development & Applications Manager UPC? & Purification, Europe & India 

14.00-15.00

Poster Session

 

BIOANALYSIS I
Mass spectrometry applications in bioanalysis

ANALYTICAL TOOLS FOR BIOPHARMACEUTICALS

15.00-15.30

KN5. On-line microfluidic capillary enrichment in bioanalysis using immunoaffinity and molecularly imprinted polymers for mass spectrometry and laser luminescence detection
H. Thomas Karnes, Virginia Commonwealth University, Richmond, VA, USA

KN6. Advanced CE-MS Systems for analysis of biopharmaceuticals
Gerhardus J. de Jong, Utrecht University, Utrecht, The Netherlands

15.30-15.50

OC11. Asymmetric flow field-flow fractionation coupled with ICP-MS for multi-element analysis of plasma proteins
Roberto Santoliquido, Alfatest srl, Rome, Italy

OC15. Biopharmaceuticals from research to routine workflows: some recent improvements
Mauro De Pra, Thermo Fisher Scientific, Amsterdam, The Netherlands

15:50-16:10

OC12. Mobilizing lung surfactant: is ion mobility mass spectrometry the way to get down to molecular basis
Barbara Pioselli, Chiesi Farmaceutici, Parma, Italy

OC16. Chemoaffinity media for analysis of topological forms of plasmid DNA
Michael Lammerhofer, University of Tuebingen, Tuebingen, Germany

16.10-16.40

Coffee break + Poster session

16.40-17.20

OC13. DMPK applications utilizing microfluidic liquid chromatography and mass spectrometry
Patrick Boyce, Waters Corporation, Herts, United Kingdom

OC17. Introduction of PAT to improve the efficiency and robustness of biopharmaceutical manufacturing
Ale? ?trancar, BIA Separations, Ajdovscina, Slovenia

OC14. Transfer of blood-placental barrier and blood-brain barrier of Oseltamvir and its metabolite in rat
Tung-Hu Tsai, National Yang-Ming University, Taipei, Taiwan

OC18. NTCB cleavage of proteins: first application for protein therapeutics quantitative analysis in mass spectrometry
Barbara Marsiglia, Merck-Serono, Colleretto Giacosa, Italy

17.20-17.50

KN7. Electromembrane extraction of drug substances and peptides from small volumes of biological fluids
Stig Pedersen-Bjergaard, University of Oslo, Oslo, Norway

KN8. Continuous chromatography (MCSGP) for the purification of therapeutic proteins
Massimo Morbidelli, ETH, Zurich, Switzerland

 

July 2

9.00-9.45

PL2
Jeremy K. Nicholson
Imperial College London, UK
Molecular Spectroscopy in the Clinical and Surgical Environments

9.45-9.50

Technical break

 

DRUG ANALYSIS II

ADVANCED ANALYTICAL TECHNIQUES FOR PROTEOMICS, GLYCOMICS, METABOLOMICS AND LIPIDOMICS II
Metabolic profiling and biomarkers for clinical applications

9:50-10:20

KN9. MALDI mass spectrometry imaging: a powerful tool in pharmaceutical and biomedical analysis 
Simona Francese, Sheffield Hallam University, Sheffield, UK

KN10. Metabolic fingerprinting of biological tissues
Coral Barbas, Universidad San Pablo - CEU, Madrid, Spain

10:20-10:40

OC19. Evaluation of the applicability of capacitively coupled contactless conductivity detection combined with separation techniques in pharmaceutical analysis
Edwin Adams, KU Leuven, Leuven, Belgium

OC26. Investigations of aberrant glycosylation of glycolipids in colorectal cancer tissues
Stephanie Holst, Leiden University Medical Center, Leiden, The Netherlands

10:40-11:00

OC20. VHPLC/HPLC method scaling when pressure and temperature affect retention
David Loyd, Bristol-Myers Squibb, New Brunswick, NJ, USA

OC27. UHPLC-MS metabolic profiling for investigating ceramides as mediators of acute oxygen sensing in vascular tissues
Alessia Ferrarini, Universidad San PabloCEU, Boadilla del Monte, Spain

11.00-11:30

Coffee break

11:30-11:50

OC21. A new approach for screening of potentially genotoxic alkylation agents
Tom van Wijk, Abbott Heathcare Products, Weesp, The Netherlands

OC28. Hydrophylic interaction liquid chromatography coupled to electrospray mass spectrometry (HILIC-MS) during the bioanalysis of amino acids in children with leukemia
Tomasz Baczek, Medical University of Gdansk, Gdansk, Poland

11:50-12:10

OC22. The simultaneous determination of hydrophobicity and dissociation constant by liquid chromatography-mass spectrometry
Pawe? Wiczling, Medical University of Gdansk, Gdansk, Poland

OC29. GC-MS metabolomics in pancreatic cancer avatar mouse models
Annalaura Mastrangelo, Universidad San PabloCEU, Boadilla del Monte, Spain

12:10-12:30

OC23. Rapid in-vitro screening for co-processed API candidate formulations using micro dissolution and UV surface imaging technologies
Xujin Lu, Bristol-Myers Squibb, New Brunswick, NJ, USA

OC30. In vivo solid-phase microextraction: novel low invasive sampling tool for monitoring of organ function during transplantation
Barbara Bojko, University of Waterloo, Waterloo, Canada

12:30-12:50

OC24. Surface acoustic wave technology as a tool for functional quality characterization of new compounds and biosimilars
Nathalie Bracke, Ghent University, Ghent, Belgium

OC31. On-line solid phase extraction - liquid chromatography-mass spectrometry to determine free sterols in human serum
Isabel Mendiara, Universidad de Zaragoza, Zaragoza, Spain

12:50-13:10

OC25. Application of the novel thin-layer chromatography – direct bioautography tests for analysis of antimicrobials
Irena Maria Choma, University of M. Curie Sklodowska, Lublin, Poland

OC32. Human urinary biomarkers of dioxin exposure: analysis by metabolomics and biologically-driven data dimensionality reduction.
Serge Rudaz, University of Geneva, Geneva, Switzerland

13.10-14.00

Lunch

14.00-15.00

Poster session

 

BIOANALYSIS II
Sample preparation and pharmacokinetic analysis

ANALYTICAL TOOLS FOR BIORECOGNITION AND BIOASSAYS

15.00-15.30

KN11. Development and application of biocompatible SPME devices
Janusz Pawliszyn, University of Waterloo, Waterloo, Canada

KN12. Exploring the dynamics of drug-protein and protein-protein interactions
Helena Danielson, Uppsala University, Uppsala, Sweden

15:30-15:50

OC33. Direct determination of blood to plasma ratio by on-line SPE-LC-MS/MS
Karl-Siegfried Boos, Laboratory of BioSeparation, Munich, Germany

OC38. Immobilized peroxisome proliferator-activated receptors (PPARs) as targets for biochromatographic studies useful in medicinal chemistry investigations
Enrica Calleri, University of Pavia, Pavia, Italy

15:50-16:10

OC34. Cocktail approach for in vitro phenotyping of major CYP450 in HLM using UHPLC-QTOF
Dany Spaggiari, University of Geneva, Geneva, Switzerland

OC39. The preparation and application of phospholipid containing monolithic column
Zhengjin Jiang, Jinan University, Guangzhou, China

16:10-16:30

OC35.Parallel artificial liquid membrane extraction (PALME) – a new direction in the field of high-throughput liquid-liquid microextraction
Astrid Gjelstad, University of Oslo, Oslo, Norway

OC40. Microfluidic system with optical detection – new tool for rare genetic disorders diagnostics
Radoslaw Kwapiszewski,Warsaw University of Technology, Warsaw, Poland

16.30-17.00

Coffee break + poster session

17:00-17:20

OC36. Microdosing of a stable-labeled IV drug for the determination of the absolute bioavailability of Daclatasvir: selection of the stable-labeled analogue and development of a sensitive LC-MS/MS assay
Anne-Fran?oise Aubry, Bristol-Myers Squibb, Princeton, NJ, USA

OC41. Development of a miniaturized bio-analysis methodology for discovery of biopharmaceuticals by coupling nano-LC to mass spectrometry and microfluidics biochemical detection
Jeroen Kool, VU University, Amsterdam, The Netherlands

17:20-17:40

OC37. Chemical imaging of small molecules from simple to complex matrices: quantitative approaches based on surface enhanced Raman scattering
Charlotte De Bleye, University of Li?ge, Li?ge, Belgium

OC42. Target-based screening of plant secondary metabolites to identify new anti-Hsp90 agents
Fabrizio Dal Piaz, University of Salerno, Fisciano, Italy

17.40-18.10

KN13. Monodisperse molecularly imprinted polymers for bioanalysis
Jun Haginaka, Mukogawa Women's University, Nishinomiya, Japan

KN14. The application of multimode optical spectroscopy and CD in drug discovery and delivery
Alex F. Drake, King’s College, London, UK

 

July 3, 2013

 

DRUG ANALYSIS III
Chiral separation and quality by design

BIOANALYSIS III
Doping and Forensic Analysis

9.15-9.45

KN15. Recent development in HPLC enantioseparation of chiral drugs with polysaccharide-based chiral selectors
Bezhan Chankvetadze, Tbilisi State University, Tbilisi, Georgia

KN16. Oral fluid cannabinoids: how analyte and cutoff selection impact drug interpretation
Marilyn A. Huestis, National Institute on Drug Abuse, N.I.H., Baltimore, MD, USA

9.45-10.05

OC43. The role of mobile phase in the enantioseparation with polysaccharide-based stationary phases
Roccaldo Sardella, University of Perugia, Perugia, Italy

OC48. Disposition of morphine and codeine in blood and in brain samples in cases of fatal heroin overdose
Gabriella Roda, University of Milan, Milan, Italy

10:05-10:25

OC44. Enantioselective normal phase HPLC-UV and HPLC-MS methods for  aliphatic esters of ?-aryl-substituted ?-amino acids
Vladimir Ioffe, Teva Pharmaceutical Industries, Ltd., Netanya, Israel

OC49. Doping control analysis of fifteen bioactive peptides in horse urine by liquid chromatography – high resolution mass spectrometry
Gary N.W. Leung, Racing Laboratory, The Hong Kong Jockey Club,Hong Kong, China

10:25-10:45

OC45. Computational chiroptical spectroscopy of bioactive molecules: the influence of conformational flexibility and solvation
Daniele Tedesco, University of Bologna, Bologna, Italy

OC50. Use of miniaturized techniques in forensic and pharmaceutical analysis: recent results
Salvatore Fanali, Institute of Chemical Methodologies – CNR, Monterotondo, Italy

10.45-11.15

Coffee break

11.15-11.35

OC46. Design quality in your capillary electrophoresis method
Cari S?nger - van de Griend, Kantisto BV, Baarn, The Netherlands

OC51. Solid-phase microextraction: a powerful tool for high-throughput sample preparation in laboratory analysis of prohibited substances
Krzysztof Gorynski, Collegium Medicum in Bydgoszcz, NCU in Torun, Bydgoszcz, Poland

11:35-11:55

OC47. Enhanced selectivity for method development using one-segment-per-component multi-segment optimization strategies
Eva Tyteca, Vrije Universiteit Brussel, Elsene, Belgium

OC52. LC selectivity studies for legal-high drugs
W. John Lough, University of Sunderland, Sunderland, UK

11.55-12.40

PL3
Irving W. Wainer
National Institute of Aging, N.I.H., Baltimore, MD, USA
Indirect pharmacological cascades: A new approach to drug discovery?

12.40-13.00

Closing remarks